Polynucleotides Wimbledon

Polynucleotides are regenerative injectable treatments designed to support skin repair, hydration and collagen activity. Unlike dermal fillers, they are not used to add volume, but to improve skin quality, texture and firmness with subtle, natural-looking results.

They are often used in areas where the skin has become thinner, duller or less supported over time, especially around the under-eyes, face, neck and hands. The aim is to improve the condition of the skin itself, rather than change facial shape.

Polynucleotides are derived from highly purified DNA fragments and are used to support the skin’s natural repair processes. Over time, treatment may help the skin look smoother, fresher and better hydrated, with gradual improvement in fine lines, texture and overall skin quality.

If you would like a fuller explanation, see my guide on how Polynucleotides work and what they may help with.

Polynucleotides work by supporting the skin’s natural repair processes. Once injected, they help create a healthier environment for regeneration by encouraging hydration, fibroblast activity and collagen support within the treated area.

In simple terms, this means they are used to improve the quality and condition of the skin itself. Over time, treatment may help the skin look smoother, better hydrated and more resilient, with gradual improvement in texture, fine lines and overall skin quality.

Polynucleotides are also valued for their protective and regenerative properties, which is one reason they are often chosen for delicate areas such as the under-eyes, as well as areas affected by thinning, crepey skin or early signs of ageing.

If you would like a broader explanation, you can also read my guide on how Polynucleotides work and what they may help with.

If you would like to understand the treatment in more detail, I explain this in my guide to what polynucleotides do to your skin.

Polynucleotides are most commonly used on the face, but they can also be used on the neck, décolletage and hands, where the skin often becomes thinner, drier or less firm over time. In some cases, they may also be used on other areas of the body, depending on the concern being treated.

They are especially popular for the under-eye area, which is often one of the first places to show visible change. Because the skin here is thin and delicate, Polynucleotides are often chosen when the goal is to improve skin quality, hydration and support in a subtle, natural-looking way.

If your main concern is the under-eye area, you may also find my guide to polynucleotides under eyes helpful.

Polynucleotide results develop gradually, so it usually takes around 2–3 weeks to start appreciating the early benefits. Because the treatment works by supporting the skin’s natural repair processes, improvement is not immediate in the way it can be with some other injectables.

Some patients notice an early improvement after the first session, but a course of 3 treatments, spaced around 2–3 weeks apart, is usually recommended for the best and most lasting results. After that, maintenance treatment is often advised every 6 months.

The number of sessions depends on the area treated, skin quality and your starting point. I explain this in more detail in my guide to how many polynucleotide sessions you may need.

To understand what kind of changes are realistic, you can also read my guide to polynucleotides before and after results.

Results from Polynucleotide treatment often last around 6 months, although this can vary from person to person. Some patients find the effects last longer, especially after completing the recommended course of treatment.

How long the results last depends on the area treated, your skin, your treatment plan and wider factors such as lifestyle and skincare. One maintenance treatment is often advised every 6 months to help preserve the result.

For a more detailed explanation of results, treatment courses and maintenance, you can read my guide to how long polynucleotide injections last.

Downtime is usually minimal, and most normal daily activities can be resumed shortly afterwards, with a few temporary restrictions. It is common to have some mild redness, swelling or small bumps at the injection sites, which usually settle within 24–48 hours. For that reason, I would usually suggest avoiding important face-to-face plans for the rest of the day if possible.

As with any injectable treatment, there is also a small risk of bruising. If bruising does occur, it can usually be covered with makeup after 24 hours and typically settles within about a week.

Polynucleotide treatment is generally well tolerated when used appropriately and after a careful consultation. As with any injectable treatment, there can be some temporary redness, swelling, tenderness or bruising at the injection sites, but these effects usually settle within a few days.

There is also a small risk of infection or other complications, which is why treatment should always be carried out in a safe clinical setting with proper assessment, technique and aftercare.

One reason many patients like Polynucleotides is that they are used to improve skin quality rather than create dramatic volume or change facial shape. However, suitability still matters, and not every treatment is right for every patient.

Polynucleotide treatment does involve a series of small injections, so some discomfort is to be expected. Most patients describe it as manageable, often more like a brief sting or pinch rather than significant pain.

The level of discomfort varies from person to person and also depends on the area being treated. Numbing cream is used beforehand to make the treatment more comfortable if needed.

Polynucleotides are not suitable for everyone, which is why a careful consultation always comes first. Treatment is usually avoided if you are pregnant or breastfeeding, have an active skin infection in or near the treatment area (including cold sores), have a fish allergy, or are known to be allergic to any of the ingredients.

They may also not be suitable if you have certain medical conditions affecting the immune system. In addition, it is usually best not to plan other injectable or energy-based facial treatments too close to your Polynucleotide treatment, including anti-wrinkle injections, dermal fillers, chemical peels, laser or ultrasound-based procedures.

If you are unsure whether Polynucleotides are right for you, I can assess your medical history and treatment plans during consultation.

Profhilo and Polynucleotides are both injectable skin treatments, but they work in different ways. Profhilo is based on hyaluronic acid and is often chosen when the main goal is intense hydration and overall skin glow.

Polynucleotides do not contain hyaluronic acid, and are used to support skin repair, hydration and collagen activity in a more regenerative way, with gradual improvement in skin quality, texture and firmness over time.

One important difference is that Polynucleotides are often considered for delicate areas such as the under-eyes, where Profhilo is generally not used in the same way. Depending on your skin concerns, the two treatments can sometimes be combined as part of a personalised plan.

Although both treatments are injected, they are used for very different reasons. Dermal fillers are used to add volume, shape and structure, while Polynucleotides are used to improve skin quality, texture and firmness over time.

Unlike hyaluronic acid fillers, Polynucleotides do not create an immediate volumising effect. Their action is more gradual, because they work by supporting the skin’s natural repair processes rather than filling an area directly.

This means Polynucleotides are often chosen when the goal is to improve the condition of the skin itself, while fillers are more suitable when volume loss, contour or definition are the main concern. In some cases, the two can work very well together as part of a personalised treatment plan.

For a broader comparison of treatment options, see my guide to Botox, Profhilo, Fillers & Polynucleotides: Find Your Best Fit.

Yes, in many cases Polynucleotides can be combined with other injectable treatments as part of a personalised plan. They are often used not only for skin regeneration in their own right, but also to help prepare and support the skin alongside treatments such as anti-wrinkle injections, dermal fillers and Profhilo.

Because Polynucleotides focus on skin quality rather than volume, they can work well with other treatments that address different concerns. The right combination, however, depends on your skin, your goals and the timing of treatment, which is why this is always best planned carefully during consultation.

A 2 week interval is advised before or after anti-wrinkle injections and dermal fillers.

You can get your Polynucleotide treatments in London at Dr Mohan’s Cosmetic Skin Clinic in Wimbledon.

We offer Polynucleotide treatments to customers from all over the UK, especially those living in Raynes Park, Kingston, Earlsfield, Clapham Junction, Putney, Wandsworth, Fulham, Surbiton and Hampton.

Our Garden Room provides a safe, secluded, and relaxed environment for all appointments, and I am always available to answer any questions.

Get in touch for a free consultation: 07702 389 636 / info@drmohanclinic.co.uk